Ozempic has been heralded as a lifechanging medicine, with this famous weight loss drug having led to millions of people around the world shedding fat.
The weight loss medicine has helped boost the self-esteem of many, and has sold a huge number of units – owing to its popularity.
However, is there an implication for mental health? Does Ozempic impact our mental health in any way? We take a look at these questions below.

What is Ozempic?
Strictly speaking, Ozempic is a prescription-only injectable medicine that is used to treat Type 2 Diabetes in adults.
However, many people are getting the drug prescribed purely for the purpose weight loss. It has become incredibly popular due to its effect of suppressing appetite, allowing weight loss to ensue.
Those that have used Ozempic includes several celebrities. For example, Elon Musk, Oprah Winfrey, and Rebel Wilson are among those who have praised it.
Ozempic is the brand name of the medicine, with the official name being Semaglutide. Semaglutide belongs to a group of medicines called GLP-1 agonists.
Ozempic is a well-researched medicine. Research into the drug has consistently found that it correlates with weight loss [1].
Ozempic’s effect on mental health
While Ozempic has proven very popular, there have been some concerns raised by various parties.
For example, in July 2023, the Icelandic Medicines Agency reported two cases of suicidal ideation, and one of self-harm. The European Medicines Agency announced that they were reviewing the situation [2].
There are stories online from many people who have attributed Ozempic to causing symptoms of anxiety or depression.
Following an investigation, the US Food and Drug Administration concluded that there was no evidence that medicines like Ozempic cause suicidal ideation [3].
Moreover, Ozempic can cause some physical side effects, including vomiting and cardiovascular problems. Experiencing such side effects can also impact mood and general mental wellbeing.
Then it is also apparent that Ozempic doesn’t work for everyone. For those that have had long-term weight issues, they may pin significant hope on Ozempic.
Many people have complained online about the drug not working. Therefore, many people are left bitterly disappointed, affecting their mood and overall wellbeing.
However, a large research study conducted by the University of Oxford and the Medical Research Council, found that Ozempic had no increased risk of adverse psychiatric outcomes when compared to other antidiabetic medicines [4].
On a wider note, another study found that the wider class of drugs that Ozempic belongs to (GLP-1 agonists), are not linked to suicidal ideation [5].
Similarly, there have even been some suggestions that Ozempic could be used in the treatment of common mental health conditions like anxiety or depression.
Then it is also important to mention the potential improvements in mental wellbeing due to the weight loss aspect. Many people find Ozempic gives them more confidence and boosts self esteem – aiding their mental health.
Additionally, the vast majority of medicines can in some cases be associated with mental health problems – it isn’t just Ozempic. Everyone reacts differently to medicines.
Summary
Ozempic is flying off the shelves for a reason – many people have found that it has transformed their life, making them healthier, boosting their self esteem and improving their quality of life.
But as with any medicine, it is important to exert caution. For all the positives, adverse reactions do seem possible.
See Also
- Can You Get Addicted to Mental Health Medicines?
- What is the Difference Between Generic and Branded Medication?
- What Are Controlled Medicines? Explanation of Controlled Drugs
- What Is The Difference Between Dependence, Tolerance, Addiction and Withdrawal?
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References
[1] Vambe, S. D., Zulu, W., Hough, E., Luvhimbi, M. J., Rwizi, S., & Bronkhorst, E. (2024). Semaglutide (Ozempic®): a comprehensive review of its pharmacology, efficacy, and safety profile in type 2 diabetes mellitus and weight management. SA Pharmaceutical Journal. 91 (6).
[2] European Medicines Agency. (2023). EMA statement on ongoing review of GLP-1 receptor agonists. Available: https://www.ema.europa.eu/en/news/ema-statement-ongoing-review-glp-1-receptor-agonists. Last accessed: 13th January 2025.
[3] US Food and Drug Administration. (2024). Update on FDA’s ongoing evaluation of reports of suicidal thoughts or actions in patients taking a certain type of medicines approved for type 2 diabetes and obesity. Available: https://www.fda.gov/drugs/drug-safety-and-availability/update-fdas-ongoing-evaluation-reports-suicidal-thoughts-or-actions-patients-taking-certain-type. Last accessed: 13th January 2025.
[4] De Giorgi, R., Koychev, I., Adler, A. I., et al. (2024). 12-month neurological and psychiatric outcomes of semaglutide use for type 2 diabetes: a propensity-score matched cohort study. eClinicalMedicine. 74 (102726). DOI: https://doi.org/10.1016/j.eclinm.2024.102726.
[5] Wang, W., Volkow, N. D., Berger, N. A., Davis, P. B., Kaelber, D. C., & Xu, R. (2024). Association of semaglutide with risk of suicidal ideation in a real-world cohort. Nature Medicine. 30. p168-176. DOI: https://doi.org/10.1038/s41591-023-02672-2.

































